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New therapy for ovarian cancer in rats

The researchers said the treatment, which is based on the use of nanotechnology to transport genetic material into cells, could be ready for human trials within a year.
"What we did was manage DNA that tells cells to die. But only active in ovarian cells, "said Dan Anderson of the Massachusetts Institute of Technology, who worked on the study published in the journal Cancer Research.
If successful, the technology offers promise for a new treatment for ovarian cancer, a disease that kills 15,000 women annually in the U.S. alone.
The study highlights the potential of nanotechnology, which involves the design and manipulation of tiny synthetic particles, as a way of bringing non-viral DNA into the cells.
"People have had success with (the therapy) virus, but they have generated certain security problems," Anderson said in a telephone interview.
The team's solution was to create a biodegradable polymer with an "artificial virus" that can enter cells and be absorbed by the body, just as biodegradable sutures work.
"We think it has a number of advantages, including security," said Anderson, who worked with a team from the Lankenau Institute in Pennsylvania. "In this case, we show that have therapeutic potential for ovarian cancer," he added.
The researchers tested different compounds until they found a biodegradable polymer that would be a vehicle suitable emitter.
to form the nanoparticle, the polymers are mixed with a gene that produces a modified form of diphtheria toxin that is only harmful to cancer cells de ovario.
"Estas partículas están diseñadas para ser absorbidas por las células y el ADN puede ser liberado en el núcleo, donde necesita estar para hacer su trabajo", manifestó Anderson.
Cuando los expertos inyectaron el tratamiento en la cavidad abdominal de los animales con cáncer de ovario, la terapia nanotecnológica funcionó tan bien o mejor que la combinación de quimioterapia tradicional con cisplatina y paclitaxel, que puede causar daño en el ADN y otros efectos colaterales.
"Hallamos que estas cosas son al menos igual de eficaces, pero más seguras", dijo Anderson.
El equipo realizará varias pruebas more and is perfecting the manufacturing process, and seek a suitable partner to begin testing the treatment in humans.
Anderson called the study on ovarian cancer is only a demonstration of the potential uses of nanoparticles in nonviral gene therapy.
The team plans to evaluate the effect of genetic emission of toxins through nanoparticles in brain tumors, lung and liver.

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