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Canadian researchers get reverse multiple sclerosis in mice

A new treatment has managed to reverse the devastating autoimmune disorder multiple sclerosis in mice. Responsible for this finding against a disease that, at present, no treatment at all in humans, is a group of researchers at the Jewish General Hospital Lady Davis Institute and the University McGill in Montreal. At the moment the rodents are the only beneficiaries of the therapy, although researchers have noted that study its application in humans.

multiple sclerosis, a disease of the nervous system that affects approximately 40,000 people worldwide, is a disease caused by the body which gives the immune response itself and attacks the central nervous system. Almost as if the body had developed an allergy itself. Its consequences are progressive physical and cognitive disabilities, with highly disabling effects. The first symptoms of the disease include blurred vision, slurred speech, loss of sensation in the limbs and loss of balance. The symptoms common to other diseases, early diagnosis makes it complicated.

suppress the immune response. This is the mechanism that underlies the treatment, called GIFT15, unlike the response suppression treatments that had previously been tested, not based on chemical pharmaceuticals, but a personalized cell therapy that uses the body's own cells to suppress the immune response.

The new therapy is composed of two proteins, fused artificially in the laboratory. Under normal circumstances, each of them acts as a stimulant of the immune system. But in its merged form, get reversed themselves. "Metaphorically, we created a chimera, a mythological these animals have the head of an eagle and the body of a lion," said Dr. Jacques Galipeau Lady Davis Hospital, director of the team responsible. The new protein, resulting from the merger of the two has a totally unexpected biological effect. This effect becomes B cells, common-form cells responsible for immune-answer in response powerful eliminator cells, similar to T cells

For treatment to be effective in mice, the disease should be treated in its early stage. In their experiment, the researchers found no side effects in rodents, which responded to the priest after the first dose. Now the challenge is humane treatment. The procedure would be to remove the patient's B cells, and treatment in the laboratory with GIFT 15. The transformed cells again be donated to the patient. As explained Galipeu, a priori is an acceptable purpose as long as it has the adequate funding.

One novelty of the treatment according to its discoverers is that, being a suppressor of the immune response might also be effective against other autoimmune disorders, such as disease Crohn's, lupus and arthritis. And even could be considered its application to control the immune response in patients with organ transplants.

Source Technorati Tags: research, health